The rising power of Islam eventually pushed the Knights out of their traditional holdings in Jerusalem. After the fall of the Kingdom of Jerusalem (Jerusalem itself fell in 1187), the Knights were confined to the County of Tripoli and when Acre was captured in 1291 the order sought refuge in the Kingdom of Cyprus. Finding themselves becoming enmeshed in the politics of that kingdom, their Grand Master Guillaume de Villaret created a plan of acquiring their own temporal domain, selecting Rhodes to be their new home. His successor Fulkes de Villaret executed the plan, and on August 15, 1309 after over two years of campaigning, the island of Rhodes surrendered to the knights. They also gained control a number of neighboring islands, as well as the Anatolian ports of Bodrum and Castellorizon.
The Knights Templar were dissolved in 1312 and much of their property was given to the Hospitallers. The holdings were organized into eight tongues (one each in Provence, Auvergne, France, Italy, Aragon, Castile, Germany and England). The English prior at the time was Philip Thame, who acquired the estates allocated to the English tongue from 1330 to 1358. On Rhodes, now known as the Knights of Rhodes they were forced to become a more militarized force, fighting especially with the Barbary pirates. They withstood two invasions in the 15th century, one by the Sultan of Egypt in 1444 and another by Mehmed II in 1480, who after the fall of Constantinople made the Knights a priority target.
However in 1522 an entirely new sort of force arrived when 400 ships under the command of Suleiman the Magnificent delivered 200,000 men to the island. Against this force the Knights had about 7,000 men-at-arms, and the walls of the city. The resulting siege lasted six months, at the end of which the survivors were allowed to leave Rhodes and retreated to the Kingdom of Sicily. In exchange, the knights promised to leave Suleiman's minions in peace. It would not be a promise they would keep.